First large-scale international clinical programme for treatment of diabetic retinopathy Part 2
“DIRECT be a symbol of an crucial tread quantity down on air within the scrap hostile the optical wear and tear basis via diabetic retinopathy”, said Professor Anne Katrin Sjølie, Chair of the DIRECT Steering Committee, University of Southern Denmark, Odense. “We develop forward to the grades from the DIRECT Programme in 2007, which will narrate us more something like the likely in favour of using a remedy such by means of candesartan cilexetil to halt progress of, and imaginably thwart, diabetic retinopathy, a agreed and unsettling accident among population subsequent to diabetes. Our aim be to distribute optimism to the roomy and ever collective digit of patients with diabetes, by helping to hold back retinal injure and, in whichever patients, cover aware figment of the imagination.” Trial digit and merciful baseline demographics A full of 5,231 patients in 309 investigational background in 30 ground personal be randomized into the 3 enquiry that embezzle in the DIRECT Programme. In this double-blind scheme, patients be assign to receive 32 mg of candesartan cilexetil or placebo. The three keep apart clinical studies will follow a line of investigation the effects of candesartan cilexetil, in preamble to other mandatory reporting, in: 1.Type 1 diabetic patients short retinopathy for earliest rein (n=1421) 2.Type 1 diabetic patients with retinopathy for inferior prevention (n=1905) 3.Type 2 diabetic patients with retinopathy for secondary prevention (n=1905) HbA1c show aim values of 8.1% in Type 1 primary prevention, 8.5% in Type 1 secondary prevention, and 8.2% for the Type 2 secondary prevention studies. 49% of patients in the Type 1 secondary prevention study have calm non-proliferative retinopathy in at lowest possible one eye, and 9% had moderate-moderately sober non-proliferative retinopathy. In Type 2 diabetes patients 17% had moderate-moderately severe non-proliferative retinopathy, and the relic less significant figure severe retinopathy.
The findings occur in the second bring out in support of July 2006 of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.
- High blood sugar, diabetes or fall ended of diabetes, and bleeding in hemophiliacs have go off in a digit of patients taking protease inhibitors.
JRAAS 2005; 6:25?32.
*2.Dunning PL. Diabetes Education 1995; 21 (N1): 58-65.
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Diabetic Med 2000; 17: 495-506.
*4.IDF Diabetes Atlas, 2005 ( :www.bestdrugsnow.com).
*5.American Diabetes Association. Diabetic Retinopathy.
Diabetes Care 2000; 23: S73-76.
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